publications
publications
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ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia
Journal of Cell Biology
G. Kreider-Letterman, A. Castillo, E.K. Mahlandt, J. Goedhart, A. Rabino, S. Goicoechea, R. Garcia-Mata
ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice
PLoS Pathog. 2021 Jul 9;17(7):e1009713. doi: 10.1371/journal.ppat.1009713
P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer
Cancers, 12(2), 480, 2020.
MJ Baker, MC Abba, R Garcia-Mata and MG Kazanietz.
Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio
Mol Biol Cell. 2017 May 3. pii: mbc.E16-06-0412. doi: 10.1091/mbc.E16-06-0412. PMID: 28468978 (featured on the cover).
A. Valdivia, S.M. Goicoechea, S. Awadia, A. Zinn and R. Garcia-Mata, Mol Biol Cell. 2017 May 3. pii: mbc.E16-06-0412. doi: 10.1091/mbc.E16-06-0412. PMID: 28468978 (featured on the cover).
I’m coming to GEF you Regulation of RhoGEFs during cell migration
Cell Adhesion & Migration 8:4, 1–15; 2014
SM Goicoechea, S Awadia, and R Garcia-Mata, Cell Adhesion & Migration 8:4, 1–15; 2014 . PubMed
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus
Nat Cell Biol. 2014 Apr; 16(4):376-81 doi: 10.1038/ncb2927.
Guilluy C, Osborne LD, Van Landeghem L, Sharek L, Superfine R, Garcia-Mata R, Burridge K.
The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.
Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C490-8. doi: 10.1152/ajpcell.00138.2012.
Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER.
The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity
PLoS Pathog. 2012 Feb;8(2):e1002543
Krishna Subbaiah V, Massimi P, Boon SS, Myers MP, Sharek L, Garcia-Mata R, Banks L.
Fixing the GAP: The role of RhoGAPs in cancer
European Journal of Cell Biology, 2022 Feb 10;101(2):151209.
doi: 10.1016/j.ejcb.2022.151209.
Evaluation of active Rac1 levels in cancer cells: a case of misleading conclusions from immunofluorescence analysis
J Biol Chem. 2020 Oct 2;295(40):13698-13710. doi: 10.1074/jbc.RA120.013919.
MJ Baker , M Cooke , G Kreider-Letterman , R Garcia-Mata , PA Janmey, MG Kazanietz, J Biol Chem. 2020 Oct 2;295(40):13698-13710. doi: 10.1074/jbc.RA120.013919. Epub 2020 Aug 14. PubMed
SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility
Journal of Cell Biology, 218 (8), 2699-2725, 2019.
Awadia, S., Arnold, T., Goicoechea, S. , Hou, T., Sun YJ., Kreider-Letterman, G. Massimi, P., Banks L., Fuentes E.J., Miller, A.J., Garcia-Mata, R.
A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells
Journal of Cell Science 2017 : doi: 10.1242/jcs.195552
Silvia M. Goicoechea, Ashtyn Zinn, Sahezeel S. Awadia, Kyle Snyder, Rafael Garcia-Mata, Journal of Cell Science 2017 : doi: 10.1242/jcs.195552. PubMed
Arrested detachment: a DEPDC1B-mediated de-adhesion mitotic checkpoint
Dev Cell. 2014 Nov 24;31(4):387-9.
Garcia-Mata, R. Dev Cell. 2014 Nov 24;31(4):387-9.
Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts
Oncogene. 2014 Mar 6;33(10):1265-73.
Golgi Membrane Dynamics and Lipid Metabolism
Current Biology, 22, R414-R424.
Vytas A. Bankaitis, Rafael Garcia-Mata, and Carl J. Mousley. 2012.
Analysis of the role of RhoGDI1 and isoprenylation in the degradation of RhoGTPases
Methods Mol Biol. 2012;827:97-105.
Boulter, E and Garcia-Mata, R.
FARP1, ARHGEF39 and TIAM2 are essential receptor tyrosine kinase effectors mediating Rac1-dependent cell motility in human lung cancer.
Cell Reports. 2021 Vol. 37 Issue 5 Pages 109905, doi: 10.1016/j.celrep.2021.109905.
Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells
Cell Commun Signal. 2020 Aug 18;18(1):129. doi: 10.1186/s12964-020-00629-3.
A. Valdivia; A. Cárdenas; M. Brenet; ; H. Maldonado; J. Diaz; M. Kong; K. Burridge; P. Schneider; A. San Martin; R. Garcia-Mata; A. F. Q. Quest; L. Leyton, Cell Communication and Signaling, 2020, 18 (1), 1-19.
The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly
Scientific Reports, volume 9, Article number: 5163 (2019)
A. Zinn, S. Goicoechea, Maity, D., Awadia, S., Cedeno-Rosario, L., Chen, Y. R. Garcia-Mata. Scientific Reports, volume 9, Article number: 5163 (2019)
mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions
Biochem Biophys Res Commun. 2017 Mar 4;484(2):255-261. doi: 10.1016/j.bbrc.2017.01.087.
Wyse MM, Goicoechea S, Garcia-Mata R, Nestor-Kalinoski AL, Eisenmann KM., BBRC 2017, Mar 4; 484(2):255-261. doi: 10.1016/j.bbrc.2017.01.087. PubMed
VAV3 mediates resistance to breast cancer endocrine therapy.
Breast Cancer Res. 2014 May 28;16(3):R53.
Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, Serra-Musach J, Islam A, Caizzi L, Di Croce L, Nevedomskaya E, Zwart W, Bostner J, Karlsson E, Pérez Tenorio G, Fornander T, Sgroi DC, Garcia-Mata R, Jansen MP, García N, Bonifaci N, Climent F, Soler MT, Rodríguez-Vida A, Gil M,Brunet J, Martrat G, Gómez-Baldó L, Extremera AI, Figueras A, Balart J, Clarke R, Burnstein KL, Carlson KE, Katzenellenbogen JA, Vizoso M, Esteller M,Villanueva A, Rodríguez-Peña AB, Bustelo XR, Nakamura Y, Zembutsu H, Stål O, Beijersbergen RL, Pujana MA. Breast Cancer Res. 2014 May 28;16(3):R53.
Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis
Eur J Immunol. 2013 Jan;43(1):281-9. doi: 10.1002/eji.201242566.
Zhang X, Tao Y, Wang J, Garcia-Mata R, Markovic-Plese S. Eur J Immunol. 2013 Jan;43(1):281-9. PDF
Affinity precipitation of active Rho-GEFs using a GST-tagged mutant Rho protein (GST-RhoA(G17A)) from epithelial cell lysates.
J Vis Exp. 2012 Mar 31;(61). pii: 3932
Waheed F, Speight P, Dan Q, Garcia-Mata R, Szaszi K. 2012
Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus
Nature Protocols,2011 Dec 1;6(12):2050-60.
Guilluy, C., Dubash, A. and Garcia-Mata, R.