publications

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Fixing the GAP: The role of RhoGAPs in cancer

Fixing the GAP: The role of RhoGAPs in cancer

European Journal of Cell Biology, 2022 Feb 10;101(2):151209.
doi: 10.1016/j.ejcb.2022.151209.

Evaluation of active Rac1 levels in cancer cells: a case of misleading conclusions from immunofluorescence analysis

Evaluation of active Rac1 levels in cancer cells: a case of misleading conclusions from immunofluorescence analysis

J Biol Chem. 2020 Oct 2;295(40):13698-13710. doi: 10.1074/jbc.RA120.013919.

 MJ Baker , M Cooke  , G Kreider-Letterman  , R Garcia-Mata , PA Janmey, MG Kazanietz, J Biol Chem. 2020 Oct 2;295(40):13698-13710. doi: 10.1074/jbc.RA120.013919. Epub 2020 Aug 14. PubMed

SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility

SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility

Journal of Cell Biology, 218 (8), 2699-2725, 2019.

Awadia, S., Arnold, T., Goicoechea, S. , Hou, T., Sun YJ., Kreider-Letterman, G. Massimi, P., Banks L., Fuentes E.J., Miller, A.J., Garcia-Mata, R.

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells

Journal of Cell Science 2017 : doi: 10.1242/jcs.195552

Silvia M. Goicoechea, Ashtyn Zinn, Sahezeel S. Awadia, Kyle Snyder, Rafael Garcia-Mata, Journal of Cell Science 2017 : doi: 10.1242/jcs.195552. PubMed

FARP1, ARHGEF39 and TIAM2 are essential receptor tyrosine kinase effectors mediating Rac1-dependent cell motility in human lung cancer.

FARP1, ARHGEF39 and TIAM2 are essential receptor tyrosine kinase effectors mediating Rac1-dependent cell motility in human lung cancer.

Cell Reports. 2021 Vol. 37 Issue 5 Pages 109905, doi: 10.1016/j.celrep.2021.109905.

Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells

Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells

Cell Commun Signal. 2020 Aug 18;18(1):129. doi: 10.1186/s12964-020-00629-3.

A. Valdivia; A. Cárdenas; M. Brenet; ; H. Maldonado; J. Diaz; M. Kong; K. Burridge; P. Schneider; A. San Martin; R. Garcia-Mata; A. F. Q. Quest; L. Leyton, Cell Communication and Signaling, 2020, 18 (1), 1-19.

The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly

The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly

Scientific Reports, volume 9, Article number: 5163 (2019)

A. Zinn, S. Goicoechea, Maity, D., Awadia, S., Cedeno-Rosario, L., Chen, Y. R. Garcia-Mata. Scientific Reports, volume 9, Article number: 5163 (2019) 

mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions

mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions

Biochem Biophys Res Commun. 2017 Mar 4;484(2):255-261. doi: 10.1016/j.bbrc.2017.01.087.

Wyse MM, Goicoechea S, Garcia-Mata R, Nestor-Kalinoski AL, Eisenmann KM., BBRC 2017, Mar 4; 484(2):255-261. doi: 10.1016/j.bbrc.2017.01.087. PubMed

ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice

ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice

PLoS Pathog. 2021 Jul 9;17(7):e1009713. doi: 10.1371/journal.ppat.1009713

P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer

P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer

Cancers, 12(2), 480, 2020.

MJ Baker, MC Abba, R Garcia-Mata and MG Kazanietz.

Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio

Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio

Mol Biol Cell. 2017 May 3. pii: mbc.E16-06-0412. doi: 10.1091/mbc.E16-06-0412. PMID: 28468978 (featured on the cover).

A. Valdivia, S.M. Goicoechea, S. Awadia, A. Zinn and R. Garcia-Mata, Mol Biol Cell. 2017 May 3. pii: mbc.E16-06-0412. doi: 10.1091/mbc.E16-06-0412. PMID: 28468978 (featured on the cover).

PubMed

I’m coming to GEF you Regulation of RhoGEFs during cell migration

I’m coming to GEF you Regulation of RhoGEFs during cell migration

Cell Adhesion & Migration 8:4, 1–15; 2014

SM Goicoechea, S Awadia, and R Garcia-Mata, Cell Adhesion & Migration 8:4, 1–15; 2014 . PubMed