Fixing the GAP: The role of RhoGAPs in cancer

European Journal of Cell Biology, 2022 Feb 10;101(2):151209.
doi: 10.1016/j.ejcb.2022.151209.

Kreider-Letterman, G. Carr, N., Garcia-Mata, R.

Evaluation of active Rac1 levels in cancer cells: a case of misleading conclusions from immunofluorescence analysis

J Biol Chem. 2020 Oct 2;295(40):13698-13710. doi: 10.1074/jbc.RA120.013919.

 MJ Baker , M Cooke  , G Kreider-Letterman  , R Garcia-Mata , PA Janmey, MG Kazanietz, J Biol Chem. 2020 Oct 2;295(40):13698-13710. doi: 10.1074/jbc.RA120.013919. Epub 2020 Aug 14. PubMed

SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility

Journal of Cell Biology, 218 (8), 2699-2725, 2019.

Awadia, S., Arnold, T., Goicoechea, S. , Hou, T., Sun YJ., Kreider-Letterman, G. Massimi, P., Banks L., Fuentes E.J., Miller, A.J., Garcia-Mata, R.

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells

Journal of Cell Science 2017 : doi: 10.1242/jcs.195552

Silvia M. Goicoechea, Ashtyn Zinn, Sahezeel S. Awadia, Kyle Snyder, Rafael Garcia-Mata, Journal of Cell Science 2017 : doi: 10.1242/jcs.195552. PubMed

FARP1, ARHGEF39 and TIAM2 are essential receptor tyrosine kinase effectors mediating Rac1-dependent cell motility in human lung cancer.

Cell Reports. 2021 Vol. 37 Issue 5 Pages 109905, doi: 10.1016/j.celrep.2021.109905.

M Cooke, G Kreider-Letterman, MJ Baker, S Zhang, N Sullivan, E Eruslanov, MC Abba, SM Goicoechea, R García-Mata*, and Marcelo G. Kazanietz* (* co-corresponding authors)

Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells

Cell Commun Signal. 2020 Aug 18;18(1):129. doi: 10.1186/s12964-020-00629-3.

A. Valdivia; A. Cárdenas; M. Brenet; ; H. Maldonado; J. Diaz; M. Kong; K. Burridge; P. Schneider; A. San Martin; R. Garcia-Mata; A. F. Q. Quest; L. Leyton, Cell Communication and Signaling, 2020, 18 (1), 1-19.

The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly

Scientific Reports, volume 9, Article number: 5163 (2019)

A. Zinn, S. Goicoechea, Maity, D., Awadia, S., Cedeno-Rosario, L., Chen, Y. R. Garcia-Mata. Scientific Reports, volume 9, Article number: 5163 (2019) 

mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions

Biochem Biophys Res Commun. 2017 Mar 4;484(2):255-261. doi: 10.1016/j.bbrc.2017.01.087.

Wyse MM, Goicoechea S, Garcia-Mata R, Nestor-Kalinoski AL, Eisenmann KM., BBRC 2017, Mar 4; 484(2):255-261. doi: 10.1016/j.bbrc.2017.01.087. PubMed

ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice

PLoS Pathog. 2021 Jul 9;17(7):e1009713. doi: 10.1371/journal.ppat.1009713

JS Bourgeois, L Wang, AF Rabino, J Everitt, MI Alvarez, S Awadia, ES Wittchen, R Garcia-Mata, DC Ko

P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer

Cancers, 12(2), 480, 2020.

MJ Baker, MC Abba, R Garcia-Mata and MG Kazanietz.

Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio

Mol Biol Cell. 2017 May 3. pii: mbc.E16-06-0412. doi: 10.1091/mbc.E16-06-0412. PMID: 28468978 (featured on the cover).

A. Valdivia, S.M. Goicoechea, S. Awadia, A. Zinn and R. Garcia-Mata, Mol Biol Cell. 2017 May 3. pii: mbc.E16-06-0412. doi: 10.1091/mbc.E16-06-0412. PMID: 28468978 (featured on the cover).

PubMed

I’m coming to GEF you Regulation of RhoGEFs during cell migration

Cell Adhesion & Migration 8:4, 1–15; 2014

SM Goicoechea, S Awadia, and R Garcia-Mata, Cell Adhesion & Migration 8:4, 1–15; 2014 . PubMed